@article{Mediastinum4957,
author = {Nobuyuki Takahashi and Chen Zhao and Arun Rajan},
title = {WT1 as an immunotherapy target for thymic epithelial tumors: a novel method to activate anti-tumor immunity},
journal = {Mediastinum},
volume = {3},
number = {0},
year = {2019},
keywords = {},
abstract = {Thymic epithelial tumors (TETs) are family of rare cancers that exhibit diverse histology and variable clinical behavior (1). A significant fraction of patients, especially those with thymic carcinoma, have locally-advanced or metastatic disease at diagnosis that is often unresectable (1). Chemotherapy is associated with objective response rates (ORR) of 50–90% in the front-line setting, but limited benefit is observed in patients with recurrent disease (1,2). With few exceptions, biological agents have not demonstrated clinically meaningful activity in relapsed or refractory TETs (3). A low tumor mutation burden and paucity of actionable biological targets creates challenges for the development of targeted therapies for TETs (4,5). Hence, there is a pressing need to develop new treatments, especially for patients with advanced thymic carcinomas.},
issn = {2522-6711}, url = {https://med.amegroups.org/article/view/4957}
}