Specific mutations in thymic epithelial tumors

Thymic epithelial tumors (TETs) are the most common primary neoplasms of the anterior mediastinum (1). The mortality of TETs except for thymic carcinoma is not very high (2), and the growth speed is not very aggressive compared with other malignancies. The standard therapy for TETs is surgical resection, and the prognosis of the thymoma patients who receive complete resection is quite good. However, therapeutic strategies for advanced or relapsed cases of TET are controversial.