AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors
Abstract

AB010. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors

Xiuxiu Hao, Xuefei Zhang, Wentao Fang

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

Correspondence to: Xiuxiu Hao. Department of Thoracic Surgery, Shanghai Chest Hospital, No. 241, West Huaihai Road, Shanghai 200030, China. Email: haoxiuxiu@vip.qq.com.

Background: There have been no specific serum biomarkers for thymic epithelial tumors (TETs) yet. The study aimed to explore the diagnostic and prognostic value of potentially relevant serum tumor markers in TETs.

Methods: We retrospectively analyzed the database of our own with the aim of reviewing the clinical records of 301 patients who have a thymic epithelial tumor after radical thymectomy, in the period between November 2012 and December 2017. Logistic regression analysis was used to evaluate relationships between tumor markers and tumor characteristics. Cox regression analysis and Kaplan Meier analysis were used to evaluate free-from-recurrence (FFR) in complete resected (R0) patients.

Results: There were 231 (76.7%) thymoma patients, 70 (23.3%) thymic carcinomas (TCs) and neuroendocrine thymic tumors (NETTs) patients in the study. The carcinoembryonic antigen (CEA), Cyfra 21-1, squamous cell carcinoma (SCC) antigen, neuron-specific enolase (NSE), and cancer antigen 125 (CA125) levels were evaluated. Elevated Cyfra 21-1, older age, higher T stage, and N stage were associated with TCs and NETTs in multivariable logistic regression analysis. In 222 patients who received R0 resection without neoadjuvant therapy, elevated Cyfra 21-1, higher T stage, and TCs and NETTs were associated with a poorer 5-year FFR in Cox regression analysis. There were significant differences in 5-year FFR between an elevated Cyfra 21-1 level and a normal Cyfra 21-1 level (42.9% vs. 92.4%, P<0.001). As for histological subtypes, TCs and NETTs were associated with a poorer 5-year FFR than thymomas (59.8% vs. 95.0%, P<0.001).

Conclusions: Serum Cyfra 21-1 level could be a potential tumor marker in the diagnosis of thymic carcinomas and NETTs, and the prognosis of recurrence.

Keywords: Cyfra 21-1; thymic tumors; tumor markers

doi: 10.21037/med-22-ab010

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://med.amegroups.com/article/view/10.21037/med-22-ab010/coif). The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/med-22-ab010
Cite this abstract as: Hao X, Zhang X, Fang W. Clinical significance of serum Cyfra 21-1 as a marker in thymic epithelial tumors. Mediastinum 2022;6:AB010.

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