Robotic resection of large anterior mediastinal masses

From a surgical standpoint, the 21^st century has been largely marked by the advancement of robotic surgery. Robotic surgery is more aptly described as computer-assisted operating with advantages of high definition 3-dimensional visualization, wristed instruments with seven degrees of motion tailored for precise and safe tissue handling, and improved ergonomics for the surgeon. Ashton et al. were the first to report successful robotic thymectomy for myasthenia gravis in a 28-year-old patient in 2003 (1). Since then, thoracic surgeons continue to apply this technology to increasingly complex thoracic surgeries. However, there has been a slower adoption for thymic malignancies due to concerns over tumor manipulation, capsular disruption, and incomplete resection (2).

Surgical treatment with complete resection is the standard of care in the management of thymic tumors. It is widely accepted that a complete R0 resection is the most important long-term prognostic factor for thymoma (3). Thymectomy via sternotomy was considered the predominant approach given the thymus’ anatomic location in the anterior mediastinum. In 2015, the European Society of Medical Oncology (ESMO) published practice guidelines that recognized minimally invasive techniques as an option for presumed Masaoka-Koga stage I/II tumors “in the hands of appropriately trained surgeons” (4). In particular, the authors stated that “robotic resection seems to provide a better visualization of the tumor when compared to VATS (video-assisted thoracoscopic surgery)”. For early stage thymic tumors, video-assisted and robotic-assisted thoracoscopic surgery seem to be oncologically equivalent to open trans-sternal surgery and even superior with regards to postoperative length of stay, complication rate, and reduced pain (4).

Historically, anterior mediastinal tumors >5 cm were considered inappropriate for minimally invasive surgery due to possible risk of incomplete resection or capsular disruption (5). However, a number of case series have demonstrated that tumor size should not be prohibitive to the benefits of minimally invasive surgery (2). Our case report, titled “A 9 cm robotic thymectomy and pericardial repair case report”, demonstrates a successful en bloc resection of a large thymoma involving the right upper lobe lung and pericardium using the robotics platform. Our case highlights the feasibility of minimally invasive techniques even with large thymomas invading adjacent structures. Our patient was subsequently discharged home on postoperative day 3 with minimal pain and narcotic requirement due to our enhanced recovery protocol (6).

“Robotic resection of anterior mediastinal masses >10 cm: a case series” by Alqudah et al. challenges the conventional size limit of 5 cm tumors by demonstrating that thymomas >10 cm could achieve a R0 resection with robotic assistance (7). Case series have demonstrated that in expert hands, the robotic approach is not only safe, but also the oncologic equivalent to open surgery for large mediastinal tumors. It should be strongly emphasized that the type of approach should not compromise achieving a R0 resection. Inexperienced surgeons should not attempt a complex thymectomy robotically if there is risk of capsule disruption or performing an incomplete resection. The International Thymic Malignancy Interest Group (ITMIG) established a set of principles for minimally invasive thymectomy to avoid compromising oncologic outcomes (8). Thymomas must be always removed together with the surrounding normal thymus and fat in order to obtain adequate safety margins. A “no-touch” technique should be utilized. The perithymic and pericardial fat is used for grasping and tractioning the tumor in order to avoid rupture of the tumor capsule and the risk of pleural implantation. Ultimately, there should be no hesitation to convert to an open approach in order to perform the appropriate oncologic operation.

Acknowledgments

Funding: None.

Footnote

Provenance and Peer Review: This article was commissioned by the editorial office, Mediastinum. The article did not undergo external peer review.

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://med.amegroups.com/article/view/10.21037/med-23-17/coif). NV serves as an unpaid editorial board member of Mediastinum from August 2022 to July 2024. NV also reports that Ziosoft paid for his registration and traveling expenses to AATS Conference in Los Angeles in 2023. The other author has no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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