AB007. A resected case of mediastinal myxoid liposarcoma: a case report
Abstract

AB007. A resected case of mediastinal myxoid liposarcoma: a case report

Takayuki Kosaka, Rikuo Ushikubo, Takashi Ibe

Department of Thoracic Surgery, NHO Takasaki General Medical Center, Takasaki, Gunma, Japan

Correspondence to: Takayuki Kosaka, MD, PhD. Department of Thoracic Surgery, NHO Takasaki General Medical Center, 36 Takamatsu-cho, Takasaki, Gunma 370-0829, Japan. Email: tkosaka133@gmail.com.

Background: Liposarcoma is a malignant soft-tissue tumor that predominantly arises in the extremities and retroperitoneum. Primary mediastinum liposarcoma is extremely rare, accounting for 0.1–0.75% of all mediastinal tumors. Histopathologically, they are classified into four subtypes: well-differentiated, myxoid, pleomorphic, and dedifferentiated types, of which the myxoid type accounts for 30–40%. Here, we report a resected case of myxoid liposarcoma of the anterior mediastinum.

Case Description: A woman in her 50s was referred for an abnormal shadow on a chest X-ray at her medical checkup. Chest computed tomography showed a 40 mm round mass on the left side of the anterior mediastinum, with progressively darker staining and some areas of poor contrast. Magnetic resonance imaging showed T2-weighted high signal in the center with minimal diffusion limitation at the margins. Positron emission tomography showed a 18F-fluorodeoxyglucose avid tumor with maximum uptake value, 2.52. Tumor markers were within normal range. Preoperative diagnosis based on radiological findings was thymoma which was Masaoka I stage. Curative surgical resection was indicated and thoracoscopic total thymectomy was performed. Intraoperative findings showed invasion of the left phrenic nerve, so a combined resection was performed. Pathological examination showed short spindle-shaped atypical cells with dense, unordered proliferation and myxoid matrix deposition in the stroma. Involvement of the left phrenic nerve and diffuse infiltration of the surrounding fatty tissue were also observed. Genomic testing revealed the FUS-DDIT3/CHOP rearrangement. Taken together, the tumor was diagnosed as myxoid liposarcoma.

Conclusions: Myxoid liposarcoma is of intermediate grade and has a relatively good prognosis compared with pleomorphic and dedifferentiated types. However, recurrence mortality rate is reported to be around 60%, and careful postoperative follow-up is necessary.

Keywords: Myxoid liposarcoma; mediastinal tumor; case report

Acknowledgments

Funding: None.

Footnote

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://med.amegroups.com/article/view/10.21037/med-24-ab007/coif). The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee(s) and with the Helsinki Declaration (as revised in 2013). Written informed consent was obtained from the patient for the publication of this case report. A copy of the written consent is available for review by the editorial office of this journal.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

doi: 10.21037/med-24-ab007
Cite this abstract as: Kosaka T, Ushikubo R, Ibe T. AB007. A resected case of mediastinal myxoid liposarcoma: a case report. Mediastinum 2024;8:AB007.

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