Vol 9 (September 30, 2025): Mediastinum [Abstract Book for the 15th International Thymic Malignancy Interest Group Annual Meeting (ITMIG 2025)]

Original Research
AB060. A predictive model for surgical resectability in thymic epithelial tumors using clinical data: a step towards integrating radiomics and histopathology
Mohammed Ghazali, Mae Shu, DuyKhanh P. Ceppa, Rohan Maniar, Patrick J. Loehrer
Mediastinum  
2025;
9:
AB060
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Original Research
AB059. Enrollment in clinical trials among Italian patients with metastatic thymic epithelial tumors: a retrospective TYME network analysis
Nadia Cordua, Giuseppe Lo Russo, Martino Tommaso De Pas, Annalisa Trama, Matteo Perrino, Claudia Proto, Fabio Conforti, Marta Aliprandi, Monica Ganzinelli, Luigi Giovanni Cecchi, Giovanni Leuzzi, Chiara Catania, Alessandro Bertocchi, Giulia Montelatici, Laura Pala, Antonio Federico, Fabio De Vincenzo, Laura Giordano, Ilaria Piloni, Paolo Andrea Zucali
Mediastinum  
2025;
9:
AB059
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Original Research
AB058. Surgical management of TNM stage IVA thymoma and thymic carcinoma: the network TYME experience (4TYMEs)
Riccardo Orlandi, Paolo Mendogni, Mario Nosotti, Annalisa Trama, Monica Ganzinelli, Giovanni Comacchio, Giovanni Leuzzi, Emanuele Voulaz, Paolo Andrea Zucali, Giulia Pasello, Irene De Simone, Francesca Galli, Giovannella Palmieri, Erica Pietroluongo, Marcello Carlo Ambrogi, Vittorio Aprile, Lorenzo Rosso; on behalf of the Italian collaborative group for ThYmic MalignanciEs (TYME)
Mediastinum  
2025;
9:
AB058
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Original Research
AB057. Two decades of robotic thymectomy: trends and insights from a retrospective study
Giovanni M. Comacchio, Alessandro Bonis, Giuseppe Cataldi, Giulia Pagliarini, Eleonora Faccioli, Marco Mammana, Giorgio Cannone, Alessandro Rebusso, Samuele Nicotra, Marco Schiavon, Andrea Dell’Amore, Federico Rea
Mediastinum  
2025;
9:
AB057
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Original Research
AB056. Surgical outcomes and prognostic impact of complete resection in thymic epithelial tumors: a 15-year experience from the National Cancer Institute of Mexico
Lilia Melissa Cruz-Cantu, Jose Francisco Corona-Cruz, Jesus Antonio Martin-Perez, Miguel Angel Salinas Padilla, Azalea Nazareth Olivares-Perez, Luis Antonio Cabrera Miranda, Federico Moreno-Avila, Oscar Arrieta, Federico Maldonado Magos, Francisco Lozano-Ruiz
Mediastinum  
2025;
9:
AB056
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Original Research
AB055. FGFR1 amplification in thymic epithelial tumors (TETs): a study from 48 cases
Véronique Hofman, Lara Chalabreysse, Jean-Philippe Dales, Romain Dubois, Audrey Mansuet-Lupo, Anne de Muret, Nicolas Piton, Isabelle Rouquette, Véronique Secq, Damien Sizaret, Vincent Thomas de Montpréville, Alice Millière, Salomé Lalvé, Pascale Missy, Clémentine Lemattre, Jonathan Benzaquen, Paul Hofman, Nicolas Girard, Álvaro López-Gutiérrez, Benjamin Besse, Thierry Jo Molina
Mediastinum  
2025;
9:
AB055
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Original Research
AB054. Survival outcomes in thymic carcinoma: a single-center experience
Erica Pietroluongo, Martina Di Meo, Lucia Salatiello, Carmine Caso, Giovannella Palmieri, Pietro De Placido, Roberto Bianco, Alberto Servetto
Mediastinum  
2025;
9:
AB054
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Original Research
AB053. The role of local therapy in oligo-recurrent metastatic thymic epithelial tumors: a monocentric retrospective analysis
Nadia Cordua, Emanuele Voulaz, Davide Franceschini, Matteo Perrino, Marta Aliprandi, Luigi Cecchi, Alessandro Bertocchi, Antonio Federico, Fabio De Vincenzo, Giuseppe Marulli, Marta Scorsetti, Paolo Andrea Zucali
Mediastinum  
2025;
9:
AB053
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Study Protocol
AB052. Indications for postoperative radiation therapy for thymic tumors based on the new ninth TNM stage classification: a protocol of a multicenter, retrospective study
Gerrit Fabian Flier, Sonja Adebahr, Tanja Schimek-Jasch, Anca Ligia Grosu, Bernward Passlick, Wolfgang Jungraithmayr, Andreas Rimner
Mediastinum  
2025;
9:
AB052
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Original Research
AB051. Immunopathological profile of patients with thymic epithelial tumour and Good syndrome in advanced stage
Anna Maria Malfitano, Erica Pietroluongo, Michele Franceso Di Tolla, Fabiana Napolitano, Vittoria D’Esposito, Rocco Morra, Alberto Servetto, Roberto Bianco, Pietro Formisano, Giovannella Palmieri
Mediastinum  
2025;
9:
AB051
.
Research Article
AB050. The thymic epithelial tumors according to the new 2021 WHO classification: Tunisian experience
Rahma Ayadi, Ichrak Hadhri, Rahma Yaiche, Yasmine Dhouibi, Emna Braham, Olfa Ismail, Nadia Ben Jamaa, Aida Ayadi
Mediastinum  
2025;
9:
AB050
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Case Series
AB049. Continuing challenges of primary neuroendocrine neoplasms of the thymus: clinicopathological characteristics of an uncommon tumor in a case series
Rahma Ayadi, Rahma Yaiche, Yasmine Dhouibi, Emna Braham, Olfa Ismail, Nadia Ben Jamaa, Aida Ayadi
Mediastinum  
2025;
9:
AB049
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Case Series
AB048. Thymoma in children, a rare mediastinal tumour: pathological case series of 6 cases and review of the literature
Rahma Ayadi, Rahma Yaiche, Yasmine Dhouibi, Emna Braham, Olfa Ismail, Nadia Ben Jamaa, Aida Ayadi
Mediastinum  
2025;
9:
AB048
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Case Report
AB047. Mixed type A thymoma and micronodular thymoma with lymphoid stroma: a case report of an unusual tumor and literature review
Rahma Ayadi, Rahma Yaiche, Yasmine Dhouibi, Emna Braham, Olfa Ismail, Nadia Ben Jamaa, Aida Ayadi
Mediastinum  
2025;
9:
AB047
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Case Report
AB046. Robotic resection of thymoma recurrence with intra thoracic phrenic nerve reconstruction using a sural nerve graft: a case report
Jamie L. R. Romeo, Jos G. Maessen, Patrique Segers, Florit D. Marcuse, Monique M. H. Hochstenbag, Hester A. Gietema, Ulrich C. Lalji, Myrurgia Abdul Hamid, Shan Shan Qiu
Mediastinum  
2025;
9:
AB046
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Case Report
AB045. Are complement inhibitors safe for thymoma-associated myasthenia gravis patients?—a literary review and case report
Angelo Luciano, Martina Di Meo, Erica Pietroluongo, Carmine Caso, Lucia Salatiello, Margaret Ottaviano, Roberto Bianco, Alberto Servetto, Giovannella Palmieri
Mediastinum  
2025;
9:
AB045
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Case Report
AB044. Late thymoma occurrence after thymectomy for thymic hyperplasia: case reports of our experience
Carmine Caso, Martina Di Meo, Lucia Salatiello, Erica Pietroluongo, Roberto Bianco, Alberto Servetto, Angelo Luciano, Margaret Ottaviano, Giovannella Palmieri
Mediastinum  
2025;
9:
AB044
.
Original Research
AB043. Comparative analysis of surgical approaches and optimal resection extent in thymoma treatment
Yi Zhang, Gaojun Lu, Kejian Shi, Xin Zhao, Hao Cui, Ku Zhang
Mediastinum  
2025;
9:
AB043
.
Observational Retrospective Study (Original Research)
AB042. Robotic-assisted surgery for large thymomas: preliminary results on feasibility and safety in a single center experience
Beatrice Trabalza Marinucci, Fabiana Messa, Giorgia Piccioni, Matteo Tiracorrendo, Alessandra Siciliani, Erino Angelo Rendina, Mohsen Ibrahim
Mediastinum  
2025;
9:
AB042
.
Original Research
AB041. Treatment response after induction therapy in unresectable thymic tumors: TYME database analysis
Giovanni Leuzzi, Federica Sabia, Claudia Proto, Giuseppe Lo Russo, Monica Ganzinelli, Alessandra Fabbri, Matteo Perrino, Nadia Cordua, Alessandro Bertocchi, Antonio Federico, Paolo Andrea Zucali, Marco Lucchi, Marcello Carlo Ambrogi, Vittorio Aprile, Paolo Mendogni, Fabiana Letizia Cecere, Giovanni Comacchio, Marianna Tortora, Marzia Di Pietro Paolo, Piergiorgio Solli
Mediastinum  
2025;
9:
AB041
.
Original Research
AB040. Subclinical myasthenia gravis after thymectomy: a 20-year retrospective cohort study
Florit Marcuse, Janneke Hoeijmakers, Myrurgia Abdul Hamid, Jamie Romeo, Jos Maessen, Stephanie Peeters, Jan Damoiseaux, Pilar Martinez, Monique Hochstenbag, Marc De Baets
Mediastinum  
2025;
9:
AB040
.
Original Research
AB039. Survival of Danish patients with thymic epithelial tumors: a nationwide cohort study
Tine Østergaard, Caroline V. A. Bjerke, Eric Santoni-Rugiu, Thomas H. L. Jensen, Katharina A. Perell, René H. Petersen, Peter M. Petersen
Mediastinum  
2025;
9:
AB039
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Original Research
AB038. A 10-year retrospective review of recurrent thymomas: a single-centre experience
Anchal Jain, Maria Isabel Leite, Rhona Taberham, Dionisios Stavroulias
Mediastinum  
2025;
9:
AB038
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Original Research
AB036. Trends in thymic epithelial tumor patients in the Netherlands: a population-based study
Marlou Dimmers, Florit Marcuse, Lex A. P. W. M. Maat, Jos G. Maessen, Jamie L. R. Romeo, Monique M. H. Hochstenbag, Stephanie T. H. Peeters, Ties A. Mulders, Jan H. von der Thüsen, Sabrina Siregar, Daphne W. Dumoulin
Mediastinum  
2025;
9:
AB036
.
Original Research
AB034. Weakly supervised artificial intelligence-based subtyping of thymic epithelial tumors using H&E whole slide images
Anna Salut Esteve Domínguez, Farhan Akram, Stephanie Peeters, Lara Chalabreysse, Nicolas Girard, Dirk De Ruysscher, Jan von der Thüsen
Mediastinum  
2025;
9:
AB034
.
Original Research
AB033. Thymic cancer in France: a comprehensive analysis of incidence based on French National Healthcare Data—a retrospective observational study
Álvaro López-Gutiérrez, Alexandre Lolivier, Jose Carlos Benitez, Jordi Remón, Adrien Rousseau, David Planchard, Fabrice Barlesi, Pernelle Lavaud, Anas Gazzah, Claudia Parisi, Pamela Abdayem, Daniela Miliziano, Lodovica Zullo, Martina Gasparro, Diego Diaz-Jimenez, Nicolas Girard, Vincent Thomas de Montpréville, Olaf Mercier, Stephanie Foulon, Benjamin Besse
Mediastinum  
2025;
9:
AB033
.
Original Research
AB032. Central pathology review of thymic tumors: updated analysis of diagnostic concordance in the French RYTHMIC cohort—a retrospective study
Álvaro López-Gutiérrez, Lara Chalabreysse, Jean-Philippe Dales, Romain Dubois, Véronique Hofman, Audrey Mansuet-Lupo, Anne de Muret, Nicolas Piton, Isabelle Rouquette, Véronique Secq, Damien Sizaret, Vincent Thomas de Montpréville, José Carlos Benítez, Angela Botticella, Daniela Miliziano, Lodovica Zullo, Pascale Missy, Jordi Remón, Nicolas Girard, Benjamin Besse, Thierry Jo Molina
Mediastinum  
2025;
9:
AB032
.
Observational Epidemiological Study (Original Research)
AB031. Global patterns and trends in thymic epithelial tumors incidence: worldwide healthcare disparity on detection
Bincheng Jiang, Zhitao Gu, Teng Mao, Wentao Fang
Mediastinum  
2025;
9:
AB031
.
Original Research
AB030. Clinical significance of SUVmax as a predictor of pathological invasion and prognostic factor in advanced thymic epithelial tumors requiring a combined resection of adjacent organs and dissemination
Satoru Okada, Shunta Ishihara, Chiaki Nakazono, Yasuo Ueshima, Masashi Yanada, Tsunehiro Ii, Kenji Kameyama, Satoshi Ikebe, Hiroaki Tsunezuka, Motohiro Nishimura, Shinya Ito, Kunihiko Terauchi, Kazuhiro Ito, Daishiro Kato, Hiroyuki Izumi, Hirofumi Suzuki, Yoshiaki Matsuura, Masanori Shimomura, Tatsuo Furuya, Masayoshi Inoue
Mediastinum  
2025;
9:
AB030
.
Original Research
AB029. Eculizumab as a new option for perioperative treatment in thymoma-associated myasthenia gravis: a prospective case series
Hui Wu, Xianglin Chu, Huahua Zhong, Liewen Pang, Lei Jin, Wenji Jia, Ran Chen, Zongtai Wu, Ji Xiong, Chongbo Zhao, Jie Song, Sushan Luo
Mediastinum  
2025;
9:
AB029
.
Original Research
AB028. Good’s syndrome and infections in a large retrospective cohort of thymoma
Wenji Jia, Sushan Luo
Mediastinum  
2025;
9:
AB028
.
Original Research
AB027. Surgery for de novo stage IVa thymomas: time to broaden our horizons?—a single-centre retrospective analysis
Giacomo Rabazzi, Vittorio Aprile, Stylianos Korasidis, Maria Giovanna Mastromarino, Alessandra Lenzini, Greta Alì, Iacopo Petrini, Marcello Carlo Ambrogi, Marco Lucchi
Mediastinum  
2025;
9:
AB027
.
Original Research
AB026. Contralateral pleura-sparing modified subxiphoid approach for robotic thymectomy: operative results, and advantages in metachronous lung cancer resection
Takao Nakanishi, Ren Takehara, Taishi Adachi, Hideki Motoyama, Mitsugu Omasa
Mediastinum  
2025;
9:
AB026
.
Case Report
AB025. When the thymus crosses the line: an unusual case of lung-infiltrating endobronchial thymoma—a case report
Giacomo Rabazzi, Vittorio Aprile, Maria Giovanna Mastromarino, Alessandra Lenzini, Stylianos Korasidis, Greta Alì, Iacopo Petrini, Marcello Carlo Ambrogi, Marco Lucchi
Mediastinum  
2025;
9:
AB025
.
Original Research
AB024. MIST: a weakly supervised deep learning system for multicenter diagnosis of mediastinal tumors
Xiaofeng Jiang, Hengrui Liang, Jianxing He, Yongtao Han, Jakob Nikolas Kather, Xuefeng Leng
Mediastinum  
2025;
9:
AB024
.
Original Research
AB023. Thymic epithelial tumors and immune system: a particular relationship still to be clarified
Emanuele Voulaz, Simone Balin, Emanuela Re Cecconi, Laura Russo, Matteo Perrino, Nadia Cordua, Silvia Della Bella, Giorgio Da Rin, Domenico Mavilio, Giuseppe Marulli, Paolo Zucali
Mediastinum  
2025;
9:
AB023
.
Original Research
AB022. Retrospective evaluation of cardiac toxicity during irradiation of thymic malignancies
Camille Fradin, Nicolas Giraud, Jennifer Tatje, Maxime Angougeard, Claudia Pouypoudat
Mediastinum  
2025;
9:
AB022
.
Case Report
AB020. Salvage surgery following definitive chemoradiotherapy and immune checkpoint inhibitor therapy for locally advanced thymic carcinoma: a case report
Ryosuke Tokuda, Satoshi Ikebe, Taishi Harada, Saki Nishimura, Masayoshi Inoue
Mediastinum  
2025;
9:
AB020
.
Original Research
AB019. Machine learning models from FDG PET/CT for predicting recurrence in thymomas
Angelo Castello, Luigi Manco, Margherita Cattaneo, Riccardo Orlandi, Lorenzo Rosso, Giorgio Alberto Croci, Luigia Florimonte, Giovanni Scribano, Stefano Ferrero, Mario Nosotti, Massimo Castellani, Gianpaolo Carrafiello, Paolo Mendogni
Mediastinum  
2025;
9:
AB019
.
Original Research
AB018. Targeted biologics for treating thymoma associated myasthenia gravis: a multicenter retrospective study
Lei Jin, Dingxian He, Hongxi Chen, Hongyu Zhou, Quantao Zeng, Song Tan, Jianquan Shi, Ying Liu, Zhangyu Zou, Jie Song, Chong Yan, Xiao Huan, Yuan Wang, Lei Yang, Jianying Xi, Zongtai Wu, Jianming Zheng, Chongbo Zhao, Xianglin Chu, Sushan Luo
Mediastinum  
2025;
9:
AB018
.
Original Research
AB017. Clinicopathologic features, treatment outcomes, and survival in thymic neuroendocrine tumors: a 25-year single-center experience
Aleksandra Piórek, Adam Płużański, Dariusz Mirosław Kowalski, Maciej Krzakowski
Mediastinum  
2025;
9:
AB017
.
Original Research
AB016. Towards understanding mechanisms of thymectomy benefit for myasthenia gravis
Henry J. Kaminski, Linda L. Kusner, Ali Taheriyoun, Keith Crandall, Ali Rahnavard
Mediastinum  
2025;
9:
AB016
.
Original Research
AB015. Perioperative outcomes and surgical strategies in malignant anterior mediastinal tumors
Hao Jiang, Hao Liang, Jingfeng Zhang, Guanying Liang, Jianqun Ma
Mediastinum  
2025;
9:
AB015
.
Original Research
AB014. Autoreactome analysis reveals novel autoantibodies in thymoma-associated myasthenia gravis
Linda L. Kusner, Taylor Bauman, Henry J. Kaminski, Jiaxin Chen
Mediastinum  
2025;
9:
AB014
.
Original Research
AB012. Short-term outcome of robotic subxiphoid-optical thymectomy for malignant thymic epithelial tumors
Masayoshi Inoue, Masanori Shimomura, Satoru Okada, Tatsuo Furuya, Chiaki Nakazono
Mediastinum  
2025;
9:
AB012
.
Case Report
AB011. Robot-assisted subxiphoid approach for resection of a giant cervicothoracic junction tumor: a case report
Yuwen Bai, Yanzhong Xin, Luquan Zhang, Xionghai Qin, Jianqun Ma
Mediastinum  
2025;
9:
AB011
.
Clinical Trial in Progress (Original Research)
AB010. A phase 1 trial of PRTH-101, a monoclonal antibody targeting discoidin domain receptor 1 (DDR1), alone or in combination with pembrolizumab, for the treatment of thymic malignancies
Funda Meric-Bernstam, So Yeon Kim, Shiraj Sen, Christopher Nabel, David Sommerhalder, Rachel E. Sanborn, Aparna Parikh, Julia Moore, Jordan Berlin, Patricia LoRusso, G. Travis Clifton, Irena Webster, Amy Mueller, Thomas Schürpf, Susan Macdonald, Joseph P. Eder, Alex Spira
Mediastinum  
2025;
9:
AB010
.
Original Research
AB009. Review of case characteristics and exploration of mechanisms of thymoma shrinkage after glucocorticoid therapy
Yang Shi, Peng Zhang, Yuan Chen
Mediastinum  
2025;
9:
AB009
.
Original Research
AB008. Analysis of natural development and changes of thymic cysts on imaging
Yuan Chen, Zirong Wang
Mediastinum  
2025;
9:
AB008
.
Original Research
AB006. Postoperative complications and early recurrence in surgically treated thymoma: a single-centre retrospective study
Zaw Tun Aung, Abdurrahmaan Manga, Sameera Gamlath, Syed Mohammad, Veeresh Patil, Jonathan Bennett, Rajini Sudhir, Sanjay Agrawal, Muhammad Majid, Elizabeth Stannard, Cathy Richards, Elizabeth Webb, Apostolos Nakas
Mediastinum  
2025;
9:
AB006
.
Case Report
AB005. Metaplastic thymoma of the mediastinum—a clinicopathological report of three cases
Po-Kuei Hsu, Yi-Chen Yeh, Min-Shu Hsieh
Mediastinum  
2025;
9:
AB005
.
Original Research
AB004. Optimizing surgical strategies in mediastinal tumor resections through comparative analysis of hemi-clamshell and sternotomy techniques
Chengyuan Fang, Jingle Lei, Xiaodong Ling, Yingnan Yang, Huiying Li, Jianqun Ma
Mediastinum  
2025;
9:
AB004
.
Original Research
AB003. Optimizing postoperative proton radiotherapy in thymic epithelial tumors: added value of breath hold?
Esther Kneepkens, Marije Velders, Judith van der Stoep, Maud Cobben, Maud van den Bosch, Nicole Hendrix, laria Rinaldi, Dirk De Ruysscher, Dianne Hartgerink, Judith Van Loon, Florit Marcuse, Stephanie T. H. Peeters
Mediastinum  
2025;
9:
AB003
.
Original Research
AB002. Histopathological heterogeneity in resected thymomas
Florit Marcuse, Monique Hochstenbag, Myrurgia Abdul Hamid, Axel Zur Hausen, Stephanie Peeters, Jamie Romeo, Jos Maessen, Pilar Martinez, Marc De Baets
Mediastinum  
2025;
9:
AB002
.
Original Research
AB001. Robot-assisted thoracic surgery for thymic epithelial tumors: a real-world study of 143 cases
Benedikt Niedermaier, Nabil Khan, Florian Eichhorn, Heidrun Grosch, Petros Christopoulos, Michael Thomas, Hauke Winter, Martin Eichhorn
Mediastinum  
2025;
9:
AB001
.


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Disclosure:

The “Abstract Book for the 15th International Thymic Malignancy Interest Group Annual Meeting (ITMIG 2025)” was commissioned by the editorial office, Mediastinum without any sponsorship or funding.