Original Research
AB028. Good’s syndrome and infections in a large retrospective cohort of thymoma
Wenji Jia1, Sushan Luo2
1Department of Neurology, No. 2 Affiliated Hospital, Kunming Medical University, Kunming, China;
2Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, Shanghai, China
Correspondence to: Sushan Luo, MD, PhD. Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, 12 Middle Wulumuqi Road, Shanghai 200040, China. Email: luosushan@fudan.edu.cn.
Background: Good’s syndrome (GS) was reported as immunodeficiency associated with thymoma and hypogammaglobulinemia. The co-existence of recurrent infections may significantly impact the quality of life and overall survival. However, these have rarely been studied in large cohorts. The study aims to report the prevalence of GS and infections in patients with thymoma and its impact on the survival.
Methods: This is a large retrospective cohort study of patients with pathologically diagnosed thymoma from Huashan Hospital, Fudan University, between May 2010 and November 2024. GS was defined as hypogammaglobulinemia with thymoma.
Results: From 1,001 patients with thymoma we have reviewed, we finally enrolled 158 cases who had peripheral immune profile evaluations. The prevalence of GS was 45.6% (72/158) while the infections were reported in 43.69% (69/158). The mortality in patients with GS was 15.28% (11/72) and 8.14% (7/86) in the non-GS group, respectively. In addition, the proportion of patients with infections was higher in the GS group (50% versus 32.72%, P=0.04). Regarding all pathogens identified from this cohort (n=121), bacteria account for the majority (52.07%, 63/121), followed by the fugus (34.71%, 42/121) and virus (13.22%, 16/121). The overall survival of 20 years was worse in patients with infections compared with those without infections [hazard ratio (HR) =6.365, P<0.001]. Patients with single paraneoplastic syndrome (PNS) had better survival outcome after 20 years than that with multiple PNS (P<0.001). However, there is no significant difference in 10-year overall survival between GS and non-GS group.
Conclusions: A substantial proportion of thymoma patients had GS and infections, which significantly impacts their survival. Early detection and intervention are essential for improving prognosis and long-term survival.
Keywords: Good’s syndrome (GS); infections; thymoma
Acknowledgments
We thank the patients for their participation in this study.
Funding: This study is supported by financial grants from the National Natural Science Foundation of China (No. 82471426), the National Key Research and Development Plan (Nos. 2022YFC3501305, 2022YFC3501303), and Shanghai Hospital Development Center Program (No. SHDC2023CRD007).
Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://med.amegroups.com/article/view/10.21037/med-25-ab028/coif). The authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki and its subsequent amendments. The study was approved by the institutional ethics board of Huashan hospital (No. NCT04535843) and individual consent for this retrospective analysis was waived.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
doi: 10.21037/med-25-ab028
Cite this abstract as: Jia W, Luo S. AB028. Good’s syndrome and infections in a large retrospective cohort of thymoma. Mediastinum 2025;9:AB028.
